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What actually matters in a clinical decision is how those differences play out in real patients

MDPI 8:549 Almahari SA, Maki R, Al Teraifi N, Alshaikh S, Chandran N, Taha H (2023) Hashimoto thyroiditis beyond cytology: a correlation between cytological, hormonal, serological, and radiological findings

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Moreover, 374 million adults have insulin resistance, presenting a high risk for T2D [1]

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However, CIs for many sensitivity analyses crossed the null (OR = 1), particularly in MR-Egger, which is known to have lower statistical power due to its reliance on stronger assumptions (e.g., Instrument Strength Independent of Direct Effect)